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PENGARUH KOMBINASI SODIUM STARCH GLYCOLATE DAN AVICEL PH 102 SEBAGAI SUPER DISINTEGRAN PADA FORMULASI ORAL DISINTEGRAN TABLET AMLODIPINE 5 MG
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Amlodipine is one of the first-line antihypertensive drugs available in tablet
form which has shortcomings, especially for patients who have difficulty
swallowing the drug, so it was developed in the form of ODT preparations. Oral
Disintregant Tablets (ODT) are tablet preparations that can be destroyed in less
than 60 seconds in the mouth. An important component in the ODT preparation
formula is the crushing agent. In this study, the crushing agent Sodium Starch
Glycolate (SSG) and Avicel pH 102 were used. SSG is a superdisintegrator with a
swelling working mechanism. Avicel pH 102 can function as a crushing agent that
uses a capillary action mechanism (wicking action). The preparation of this ODT
preparation uses the active ingredient Amlodipine Besylate and a combination of
Sodium Starch Glycolate (SSG) and Avicel pH 102 crushing agents with consecutive
concentration presentations of F1 (4:0), F2 (2:5), and F3 (2:2.5) using the wet
granulation method. This study aims to determine the influence of the use of a
combination of crushing materials and to find out what is the good composition in
the manufacture of Amlodipine ODT. With the results of the destruction time test
obtained the average and standard deviation in F1, F2, and F3 respectively, which
are 38.3 ± 0.471; 51.0 ± 0.816; and 31.3 ± 1.247. Based on these results, it can be
concluded that the three formulas are found to have the influence of a combination
of crushing materials. And a good composition is found in F3 with a faster crushing
time.
Keywords : Oral Disintregant Tablet, Amlodipine Besylate, Sodium Starch
Glycolate, Avicel pH 102, Wet Granulation.
Detail Information
| Item Type |
KARYA TULIS ILMIAH
|
|---|---|
| Penulis |
NURVIN SEPTYAN PANGESTU - Personal Name
|
| Student ID |
21013063
|
| Dosen Pembimbing |
Apt. Deny Budi Legowo, S.Farm., M.Farm - - Dosen Pembimbing 1
|
| Penguji | |
| Kode Prodi PDDIKTI | |
| Edition | |
| Departement | |
| Contributor | |
| Language |
Indonesia
|
| Publisher | Akademi Farmasi Mitra Sehat Mandiri Sidoarjo : Krian., 2024 |
| Edition | |
| Subject(s) | |
| No Panggil | |
| Copyright |
Akademi Farmasi Mitra Sehat Mandiri Sidoarjo
|
| Doi |