Text
VARIASI LAMANYA PENCAMPURAN AKHIR TERHADAP MUTU FISIKORAL FAST DISSOLVING TABLETS DOMPERIDONE BASE
- Share to:
According to (Gupta A, 2010).Oral fast dissolving tablets (OFDT) are tablet preparations that when placed on the tongue will disintegrate in less than 60 seconds. In the manufacture of tablets required binder, filler, destroyer, lubricant and coloring agent, among which the destroyer. Prostitute material is intended to guarantee the destruction of the tablet in less than 60 seconds. The active substance will then dissolve or be dispersed in the presence of saliva, then swallowed by the patient, and the drug is absorbed as usual. A small amount of saliva is expected to be sufficient to allow tablet disentegration. Therefore, no water is needed to swallow water (Koseki et al., 2008). This will facilitate and improve patient compliance in using the drug.In making tablets the mixing process is a critical parameter that needs to be reviewed, it is hoped that in a few minutes the mixing process will become more homogeneous. According to (Source: Handbook of pharmaceutical Excipients p. 404). The addition of magnesium stearath in mixing can affect the results, this is due to the formation of hydrophobes. Magnesium stearath can form a thin layer that can affect the bonding properties of these solid particles because the role of magnesium stearath causes granule flow time to get faster, angle ofrest less, and the longer time to disintegrate the tablet.