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EFFECT OF VARIATION OF LUBRICANT CONCENTRATION (MAGNESIUM STEARATE) ON THE PHYSICAL QUALITY OF METOCLOPRAMID HCl TABLETS WITH DIRECT PRINTING METHOD
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ABSTRAK
Metoklopramid HCl digunakan untuk meredakan mual dan muntah. Ketersediaan di pasaran dalam bentuk tablet, sirup dan injeksi. Penggunaan obat yang paling disukai pasien adalah obat oral karena kemudahannya dalam penggunaan. Tablet kunyah merupakan produk baru sebagai alternatif untuk pengobatan pada pasien anak-anak dan dewasa yang mengalami kesulitan dalam menelan obat. Penelitian ini bertujuan untuk memformulasi sediaan tablet kunyah metoklopramid HCl menggunakan variasi konsentrasi lubrikan yaitu magnesium stearat dengan konsentrasi 1%, 2%, dan 3% menggunakan metode cetak langsung dibuat untuk mendapatkan uji mutu fisik yang lebih baik meliputi organoleptik, keseragaman bobot, keseragaman ukuran, kekerasan tablet, kerapuhan tablet, waktu hancur tablet, keseragaman kandungan. Hasil uji mutu fisik dianalisis secara statistic menggunakan one way ANOVA untuk mengetahui pengaruh variasi konsentrasi lubrikan terhadap karakteristik tablet kunyah. Hasil penelitian menunjukkan bahwa variasi konsentrasi lubrikan magnesium stearat pada pembuatan tablet kunyah metoklopramid HCl berpengaruh terhadap mutu fisik tablet kunyah metoklopramid HCl. Konsentrasi magnesium stearat yang menghasilkan tablet kunyah metoklopramid HCl dengan sifat fisik baik adalah 2%.
ABSTRACT
Metoclopramide HCl is used to relieve nausea and vomiting. Market availability in the form of tablets, syrup and injection. The most preferred drug use by patients is oral medication because of its ease of use. Chewable tablets are a new product as an alternative for treatment in pediatric and adult patients who have difficulty swallowing drugs. Objectives: This study aims to formulate the chewable tablet preparations of metoclopramide HCl using variations in lubricant concentrations. The variations of magnesium stearate with concentrations of 1%, 2%, and 3% using the direct printing method made to obtain a better physical quality test including organoleptics, weight uniformity, uniformity of size, tablet hardness, tablet brittleness, tablet crush time, uniformity of content. The results of the physical quality test were statistically analyzed using one way ANOVA to determine the effect of variations in the concentration of lubricants on the characteristics of chewable tablets. The results showed that variations in the concentration of magnesium stearate lubricant in the manufacture of metoclopramide HCl chewable tablets had an effect on the physical quality of metoclopramide HCl chewable tablets. Conclusions: The concentration of magnesium stearate which produces metoclopramide HCl chewable tablets with good physical properties is 2%.
Detail Information
| Item Type |
JURNAL DOSEN
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|---|---|
| Penulis |
Deny Budi Legowo - Personal Name
Andri Priyoherianto - Personal Name Winda Damayanti - Personal Name Erna Fitriany - Personal Name Valiandri Puspadina - Personal Name |
| Student ID | |
| Dosen Pembimbing | |
| Penguji | |
| Kode Prodi PDDIKTI | |
| Edition |
Published
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| Departement | |
| Contributor | |
| Language |
Indonesia
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| Publisher | Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo : Gorontalo., 2021 |
| Edition |
Published
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| Subject(s) | |
| No Panggil | |
| Copyright | |
| Doi |