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Plagiarism Checker X Originality Report
Similarity Found: 3%
Date: Monday, April 29, 2019
Statistics: 4 words Plagiarized / 130 Total words
Remarks: Low Plagiarism Detected
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EVALUATION OF BENZYLIDENE-ACETONE ANALOGUES AS ANTITUBERCULOSIS CIKRA IKHDA NUR HAMIDAH SAFITRI1,2, RITMALENI1*, NING RINTISWATI3, SARDJIMAN1, TAKUSHI KANEKO4 ABSTRACT Objective: To evaluate the effect of Benzylidene Acetone analoguesues of curcumin against Mycobacterium tuberculosis H37Rv Method: The activity of Benzylidene Acetone analoguesues of curcumin is evaluated by using Mycobacteria Growth Indicator Tube(MGIT) method and Microplate Alamar Blue Assay (MABA) method.
 
Result: The MIC of 1,5-bis-3,4-dichlorophenyl-1,4-pentadiene-3-one (C9) and 1,5-bis3-chlorophenyl-1,4-pentadiene-3-one (C10) inhibit growth of Mycobacterium tuberculosis. The compounds are active at 500 μg/ml by MGIT method. Compare with MABA, C9 and C10 are active at the concentration by using MGIT method. Based on MABA method, it can be obtained similar MIC value of C9 compound and C10 compound that are 187,5 μg/ml.
 
Conclusion: The compound with chloro groups have antituberculosis activity. Keywords: curcumin analoguesues, MGIT, MABA, Tub
 
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